ALK inhibitors in the treatment of ALK-positive non-small cell lung cancer (review)
Summary. Every year, 1.8 million new cases of lung cancer (LC) are registered in the world, with 85% of non-small cell disease being diagnosed. LC is a leader in the structure of mortality from malignant neoplasms (25% of all cases of death of cancer). The standard of treatment for patients with LC are operation, chemotherapy, radiation therapy, immunotherapy and targeted therapy. Use of targeted therapy is the most personalized and perspective direction of modern oncology. In this article modern approaches to treatment of ALK positive non-small cell lung cancer (NSCLC) were analyzed. Despite the relatively small percentage of patients with ALK gene rearrangement, the definition of this mutation is extremely important. It is connected with the fact that the most effective method of treatment for patients with a translocation of ALK is use of targeted medicines — ALK inhibitors. Crizotinib was the first drug approved for the treatment of the common ALK positive NSCLC and became the drug of choice for treatment-naive patients. However, subsequent resistance has led to the development of new ALK inhibitors, such as ceritinib, alectinib, brigatinib, lorlatinib.
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