Heavy chain disease: clinical case and literature review
Summary. Heavy chain diseases (HCD) are group of chronic B-cell lymphoproliferative disorders that are characterized by production of the pathological monoclonal heavy chain of immunoglobulin (α, μ or γ), incapable to binding the corresponding light chains due to genetic mutations. The clinical manifestations of HCD depend on the isotype of the produced heavy chain and range from an asymptomatic course to aggressive lymphoma. In the article we disscussed the issues of pathogenesis, clinical picture and differential diagnostics of different types of HCD and described a clinical case of diagnosis of α-HCD.
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