Modern differential cytological diagnosis of adenocarcinoma, mesothelioma and reactive serositis

Marinenko S.V., Bolgova L.S.

Summary. The article contains general information on the use of modern immunocytochemical (ICС) method in differential cytological diagnosis of adenocarcinoma, mesothelioma, and reactive serositis. The possibilities of using the ICС method on traditional cytological preparations are shown. It has been established that for positive adenocarcinoma cells the most positive are ICС reactions to epithelial antigen (Ber-EP4) (85–90%), cancer-embryonic antigen (40–67%), epithelial-membrane antigen (60–63%); for mesothelioma a positive response to pancytokeratin (C AE1/AE3) (92–100%), cytokeratin 5/6 (44–50%), calretinin (62–100%) and vimentin (50–56%) is characteristic; in cells of reactive mesothelium, uniquely in (28%) — ICС reaction with vimentin and in 28% with calretinin.
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