Low doses opioids anesthesia during colorectal surgeries in cancer patients
Summary. The efficacy and safety of dexmedetomidine as an analgesic adjuvant drug for anesthesia during colorectal surgeries in cancer patients was studied. Saving effect of dexmedetomidine on opioids amounts was evaluated. The patients in addition to the combined intraoperative anesthesia received intraoperative infusion of dexmedetomidine after the previous administration of loading dose. Our results showed that the use of dexmedetomidine during surgery significantly decreases an amount of intraoperative opioids, reduces the intensity of postoperative pain, and can probably help to reduce the depression of the immune system and increase survival in a remote postoperative period. The use of dexmedetomidine as a component of multimodal anesthesia did not cause severe hemodynamic disorders, which suggests its safety in recommended doses.
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