In situ immune response after perioperative chemotherapy in patients with locally advanced breast cancer

Verovkina N., Sivak L.A., Lyalkin S., Krotevych M.S.

Summary. Breast cancer (BC) is one of the most widespread cancers among women in the world. To date, works devoted to the search for new approaches to treatment based on modern knowledge in the fields of experimental and clinical oncology are actual. The purpose of our research was to study the characteristics of immune infiltration in a tumor tissue and its effect on the effectiveness of neoadjuvant chemotherapy in various molecular subtypes of locally advanced BC. We found that high level of the tumor infiltrating lymphocytes was more common in patients with locally advanced BC without expression of steroid hormones receptors as compared to patients with hormone-dependent tumors (33.33% vs 13.63%; p=0.00002). It has also been investigated that an increase in the number of CD4 lymphocytes in the residual tumor increases the risk of recurrence of the disease (HR=2.1; 95% CI 1.0–4.7; p=0.03). Given the results obtained, further study of the prognostic and predictive value of the parameters of lymphoid infiltration at different molecular subtypes of breast cancer is necessary in order to include them in diagnostic and therapeutic algorithms in this disease
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