Survival comparison of patients with germinal and non-germinal center diffuse large B-cell lymphoma defined by Hans, Colomo and Muris immunohistochemistry algorithms. National Cancer Institute experience

Kriachok I.A.1, Martynchyk A.V.1, Filonenko K.S.1, Antonyuk S.A.2, Titorenko I.B.1, Stepanishyna Y.A.1

Summary. Diffuse large B-cell lymphoma (DLBCL) is clinicaly, morphologicaly and geneticaly heterogeneous group of disease. Due to signifficant influence of this heterogenity on the clinical course of disease and response to the therapy new methods for prognosis identification are needed. The new modern methods of diagnostics results into the constant improvement of subclassifications of prognostic groups. Hans’, Colomo’s and Muris’ immunohistochemical algorithms are reviewed in the article. Also there is a comparison of surviving of two subtypes defined by each algorithm. Separately survival of high and low-risk patients according international prognostic index was analysed. Hans’ algorith allow to define patients with worse survival even in low-risk patients with diffuse large B-cell lymphoma.
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