Neoadjuvant chemotherapy of cervical cancer carcinoma stage IIB — the guarantee of radical surgical intervention
Summary. The choice of cervical carcinoma treatment is determined individually and depends on the distribution process and severity of concomitant somatic pathology. The use of surgical treatment in combination with radiation therapy and/or chemotherapy leads to improved overall and disease-free survival. One of the traditional treatment of cervical carcinoma IIA is neoadjuvant chemotherapy (NACT), followed by radical surgery. The effectiveness of NACT of cervical carcinoma IIB is still being studied. Our research is based on data on the treatment of 37 patients with cervical carcinoma IIB. All patients received 3 courses of NACT (GemP). Further tactics of treatment carried out after the 3 course NACT On the basis of the examination and obtained effect. All patients were divided in 2 groups: group 1 (n=25) — patients with cervical carcinoma IIB which was registered with the objective response from NACT; group 2 (n=12) — patients with cervical carcinoma IIB have not been registered objective response or registered progression of the disease from NACT. Second step of special treatment of the 1 group of patients was a radical surgical treatment in the amount of panhysterectomy type III. The surgical activity after NACT was 67.5%. Survival of patients subjected to surgical treatment was higher than that of the unoperated patients: 82.0±3.6% and 71.0±of 2.7%, respectively. Thus, NACT of cervical carcinoma IIB has clear advantages over radiation therapy only under condition of implementation in the subsequent radical surgical intervention.
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