Modern approaches to neoadjuvant therapy in patients with esophageal cancer

Kirkilevskyi S.I., Frydel R.I., Krahmalyov P.S., Kondratskyi Y.

Summary. Esophageal cancer is characterized by highly malignant disease, which requires a comprehensive approach to its treatment. At the present stage, preoperative treatment for esophageal cancer using radiotherapy, chemotherapy, targeted therapy. Apply intravenous, intraarterial and endolymphatic routes of administration of chemotherapy. The most effective is a technique that involves neoadjuvant chemoradiotherapy followed by radical surgery. Radiotherapy is performed on linear and circular accelerators, gamma-therapy facilities. The most effective chemotherapy to treat esophageal cancer are taxanes having radiosensitizing pro­perties. Targeted therapy is a promising but little-known and often combined with conventional chemotherapy. Development of new pathogenesis-based drugs based on molecular features of tumor biology and will be applied against the backdrop of high-tech radiation therapy — a future in the preoperative treatment of aggressive tumors such as cancer of the esophagus.
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