Triple negative breast cancer: current view on the problem

Sivak L.A., Lyalkin S., Mаydаnеvich N., Klimаnоv М.Yu., Askоlskiy А.В., Kasap N.

Summary. Therapy of triple negative breast cancer (TNBC) remains one of the most difficult problems of oncology. This type of BC combines biological aggressiveness and limited number of treatment modalities, and often affects young women. From great arsenal of the contemporary BC treatment methods only chemotherapy is appropriate for TNBC. Despite the great number of the dedicated to TNBC clinical studies, at present there exist no standard chemotherapy regimen for this subtype. And results of treatment remain unsatisfactory. Actively implemented in recent years principles of maximal individualization of BC therapy are unsuccessful for the triple negative type. The article presents the review of the most significant clinical studies devoted to neoadjuvant and adjuvant chemotherapy of TNBC.
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