Treatment of pregnancy-associated lymphomas

Andreyeva N.L.1, Mavrichev S. A.2, Trukhan A. V.1

Summary. Introduction. In the modern world, the possibilities of pregnancy management in cancer, including lymphomas, are actively studied. Objective. To analyze the possibility of prolonging pregnancy among women with lymphomas. Material and methods. as based on data on 23 patients with pregnancy-associated lymphomas who received systemic chemotherapy during gestation (the main group). The control group consisted of 133 patients with lymphoma outside pregnancy. The comparison group included 74 healthy pregnant women. In an observational case-control study for the period from 01.01.2011 to 31.12.2018, the results of treatment of lymphoma during pregnancy were studied. A method has been developed that includes timely treatment of this neoplasm during pregnancy, without interrupting the latter, while not worsening the prognosis of malignancy and prolonging pregnancy until urgent delivery. Results. overall survival rate in the main group of patients with lymphomas was 100%. For the control group of patients with lymphomas, the 5-year overall survival was 96.7±1.6. there were no Differences in overall survival between the compared groups (p>0.05). For the control group, the 5-year event-free survival rate was 83.3±3.4; for the main group, the 5-year event-free survival rate was 90.2±6.6 (p>0.05). Thus, there were no statistically significant differences in survival rates (p>0.05) in the main group with a longer follow-up period. The radiation therapy stage was postponed until the postpartum period, if necessary. Conclusion. A comparative analysis of long-term treatment results for survival did not reveal statistically significant differences in the main and control groups (p>0.05).

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