The role of the tumor microenvironment in predicting the survival of patients with stage I–III colon adenocarcinoma

Shkurupii B.M.

Summary. Introduction. Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide. This study aims to investigate the prognostic value of tumor microenvironment features in patients with CRC stage I–III. Materials and methods. Retrospective study that involved 183 patients with colorectal adenocarcinoma stage I–III. The median follow-up period was 3.6 years for overall survival. Results. Kaplan — Meier curves showed that the difference in overall survival (OS) between groups with Low-TSR and High-TSR was significant (p=0.006); the difference in OS between A, B, and C groups (TILs) is statistically significant (p=0.017). Based on multivariate Cox’s proportional hazard regression model, TSR can be considered an independent prognostic factor that influences overall survival (p=0.012). Conclusions. Colorectal adenocarcinomas with high tumor stroma ratio have worse overall survival compared to low tumor stroma ratio tumors. Tumor-infiltrating lymphocytes have great potential as a prognostic tool and require deeper study.

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