Retrospective analysis of radical treatment of patients with stage III–IV larynpharyngetal cancer
Mykhailiuk P.I.1, Hirna H.A. 1, Kostyshyn I.D.1, Tsybran S.S.2, Boyko V.V. 2, Lozynsky A.Ya.2, Gumenyuk I.B.2, Stasiv O.M.2, Kryzhanivska A.E.1
- 1Ivano-Frankivsk National Medical University, Ukraine
- 2Municipal Nonprofit Enterprise «Prykarpattia Clinical Oncology Center of Ivano-Frankivsk Regional Council», Ivano-Frankivsk, Ukraine
Summary. Malignant hypopharyngeal pathology represents a significant healthcare challenge, contributing to considerable morbidity and mortality. The treatment approach for patients with squamous cell carcinoma of the hypopharynx has changed substantially over recent decades. These changes may have a notable impact on the survival of patients with this oncologic condition. Hypopharyngeal tumors are characterized by local invasion and lymphatic spread. At the time of diagnosis, lymph node involvement is present in approximately 70% of patients. The prognosis is often poor due to the advanced stage typically observed at the time of disease detection. According to National Comprehensive Cancer Network (NCCN) guidelines, treatment of stages III–IVa patients carries a significant individual burden. Studies report cardiovascular dysfunction in 75% of patients with hypopharyngeal cancer, while 68% present with respiratory system impairments. More than half of the patients are diagnosed with inflammatory diseases of the lungs and upper respiratory tract. These factors impose restrictions on the selection of treatment strategies and increase the risk of complications during surgery and in the postoperative period. The question of the appropriateness of certain components of radical treatment complicates the decision-making process for optimal patient management, even within multidisciplinary tumor boards, and remains highly relevant. Materials and methods. A retrospective analysis was conducted using archived medical records of all patients treated with curative intent for hypopharyngeal cancer from 2014 to 2023. A total of 123 patients with stages III–IVa hypopharyngeal carcinoma who underwent radical treatment at initial presentation were reviewed. Results and conclusions. Patient survival corresponds to global trends, yet improvement is needed through earlier diagnosis and the implementation of modern therapeutic approaches. Comorbid conditions significantly impact survival in patients with hypopharyngeal cancer.
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