Number Т. 9, № 4 (36) 2019

Surgical treatment of rectal cancer with synchronous liver metastasis

Schepotin I.B., Kolesnik E.A., Lukashenko A.V., Burlaka A.A., Priymak V.V.

Summary. Comparative analysis of treatment outcomes of 41 patients with metastatic rectal cancer with synchronous liver affection (sM-RC), who underwent surgical interventions in the clinic of the National Institute of Cancer from November 2008 to September 2013 was provided. The patients were rando­mized into the groups of combined (group I — resection of primary tumor and distant metastases simultaneously) and staged (group II — resection of primary tumor and distant metastases in two stages) surgical treatment. Obtained results analysis did not demonstrate statistically reliable difference in the level of early post-surgical complications in study groups according to Clavien — Dindo scale (Grade II; IIIa; IIIb; IVa) that was 4.7; 14.3; 9.5; 4.7 and 10; 10; 5; 0%, respectively, in the groups I and II. No post-surgical lethality was registered in the groups. The most serious complications (Clavien — Dindo Grades IIIb, IVa) were reported in patients of group I that underwent excision of more than 40% of liver parenchyma (hemihepatectomy + segment/section). In 3 patients (14.3%) of the group I partial colonic anastomotic leak developed in early post-surgical period; this was not registered in the group II (р=0.21). In staged resections group (group II) total cumulative 3-year survival was 40.0%, while at combined surgical approach (group I) this characteristic was reliably higher — 61.9% (р
No Comments » Add your
Leave a comment