Comparative analysis of synchronous and staged resections in patients with metastatic colorectal cancer

Schepotin I.B., Kolesnik E.A., Lukashenko A., Burlaka A.A., Priymak V.V., Lavryk G.V., Chalileev O.O. , Kutsenko L.B.

Summary. Surgical treatment of synchronous metastatic colorectal cancer (SMCLC) remains the only method that improves overall 5-year survival. For the moment the issue of feasibility and effectiveness of synchronous operative interventions application in metastatic liver lesion in patients with SMCLC remains challenging. Results of 98 MCLC patients treatment with synchronous liver lesion that received synchronous (group A, n=40) and staged (group B, n=58) liver resections in the Department of Abdominal and Retroperitoneum Tumorsofthe National Cancer Institute of the Ministry of Health Care of Ukraine in the period from 2008 till 2012. Overall 3-year survival in the group of patients with synchronous resections (group А) was 42% and in the group B was 55% (р=0,22). Overall level of post-operative complications in the groups A and B after surgical stages finishing did not differstatistically, being 30 and 35,7% in the groups А (n=40) and B (n=28), respectively (p=0,83).
Shorter operative intervention duration was registered in the group A – 316,3±10,3 min, whereas in the group B it was 484,1±18,3 min (р for alon gertime– 23,3±0,8 bed-days, when synchronous resections provided with shorter recovery terms in post-operative period — 10,2±0,4 bed-days (p necessity of the development of differentiated approachin SMCLC surgical treatment. Subsequent research should be directed towards study of prognosis factors and criteria for patients’ selection for surgical treatment groups, assessment of economic effect, and patients’ life quality.
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