Effects of tumor and concomitant pathology on morpho-functional changes in the kidneys

Krotevych M.S.1, Trokhymych S.S. 1, Koshubarova M.V. 1, Skoroda L.V.1, Vitruk Y.V.1, Voilenko O.A. 1, Kononenko O.A. 1, Stakhovsky O.E.1, Semko S.L. 1, Pikul M.V. 1, Vucalovych P.S.1, Tymoshenko A.V.1, Buivol O.V. 1, Stakhovskyi E.O.1, Pasichnyk S.M.2

Summary. The research presents a retrospective analysis of the examination and treatment results of 30 patients who underwent surgical removal of clear cell carcinoma during 2015–2019 at the National Cancer Institute. The criterion for inclusion in the study was the complete intrarenal placement of the tumor without spreading it to the kidney capsule (T1a–T2v stage, any N, any M). The aim of the research was to study the effect of tumor on morpho-functional changes in the kidneys depending on its size and the presence of systemic diseases (diabetes mellitus, hypertension, etc.). Results. The morphological research indicated the formation of a delimination zone between the tumor and the parenchyma of the kidney in the form of lymphoid cell infiltration and vascular proliferation, which directly increased with an increase in tumor size (p <0.05), and the presence of concomitant pathology accelerated and deepened the expressiveness of sclerotic changes in the form of sclerosis of the canals, progressive increase in the distance between them, thinning of their epithelium (p <0.001). Conclusions. It was found a statistically reliable inversely proportional dependence of a progressive decrease in the volume of functioning parenchyma of the kidney and a decrease in the rate of tumor filtration, which increases the size of the tumor (p <0.04), and the combination of large tumor size and concomitant pathology leads to a significant deterioration in the function of the tumor affected by the kidney tumor (p <0.02).

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