Metastatic bone lesions: molecular mechanisms as new avenues of therapeutic influence. Literature review

Solodyannуkova O.I., Bankovska N.V., Shypko A.F. , Danylenko V.V., Sukach G.G.

Summary. The paper analyzes the state of the problem in the literature regarding the molecular mechanisms of the formation of metastatic bone lesions and the use of these data in the treatment of cancer patients with bone lesions. The detection of bone metastases has been found to correlate with tumor stage, a wide range of complications, including pain, increased risk of fractures and hypercalcemia, compression of the spinal cord or other nerve structures. Understanding the mechanisms of skeletal injury (SRE), which vary in severity and duration of exposure, is an important consideration, especially when evaluating the efficacy of therapy.

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