The role of proteomic and genomic predictors of survival in patients with ovarian cancer
Summary. There was a comparative analysis of genomic and proteomic markers of prognosis of survival in patients with the ovarian cancer in the article. The authors propose in addition to well-known criteria of resistance to platinum prognosis to include such parameters as genetic history (the presence of mutant alleles of SNPs BRCA1 and BRCA2 6174delAG 5832insC in hetero- and homozygous variant, microsatellite instability), high activity of cyclins D and E, increased levels of catecholamines, high degree of expression of NO synthase, degree of hyperuricemia, active expression of receptors for epidermal growth factor and activity of CAS 20q13.
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