Efficiency of combined treatment by xenogeneic cancer vaccine and doxorubicin in the experiment

Summary. The efficiency of combined chemotherapy and vaccinotherapy using embryonic xenogenic vaccine developed in R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine is demonstrated on Lewis lung carcinoma model. The optimum scheme of combined treatment includes the administering of doxorubicin prior to surgical removal of the tumor, and the administering of vaccines at an early stage after a surgery, due to which the index of metastasis inhibition increases to 98%. It is established that the combined treatment of animals at the end of the experiment provides the increased cytotoxicity of lymphocytes and the reduced level of IgG accumulation in protein extracts from the cells of homologous tumor.