The DNA content in colon adenocarcinomas’ cells nuclei and expression of Bcl-2 and p53

Antonyuk S.A.1, Vorobey E.A. 2, Savchyn T.M.

Summary. Carried out researches 88 adenocarcinomas and benign tumors of colon, showed that these tumors have a wide range of Bcl-2 and p53 expression frequency, where their level differs and varies depending on the G and DNA content in the cells’ nuclei. Increase of DNA in the tumor’s cells nuclei is accompanied by rising correlation levels with Bcl-2 and p53 expression. Presence of Bcl-2 expression leads to more significant, than p53, increase of DNA amount in the colon adenocarcinoma nuclei. Determination of the Bcl-2 and p53 expression as independent signs of ade­nocarcinoma of the colon is uninformative, but it is significant multifactorial assessment component associated with tumor’s cells proliferative potential.
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