Effectiveness of support therapy algorithms based on chemotherapy toxicity prognostic factors in patients with breast cancer

Sivak L.A., Gubareva G.O., Lyalkin S., Mаydаnеvich N., Klimаnоv М.Yu., Aleksyk O.M., Askоlskiy А.В.

Summary. Chemotherapy is a mandatory component of combined treatment of patients with locally advanced or metastatic breast cancer. Toxicity of chemotherapy should be considered with a view to the prevention and adequate treatment, as it: adversely affect the quality of life of patients both during treatment and at follow-up, makes it necessary to reduce the dose of cytotoxic drugs, increase the intervals between cycles and stop cancer treatment, can be life-threatening, significantly increases the cost of treatment. Application of the algorithm of support therapy in standard chemotherapy regimens in patients with malignant breast tumors with a high risk of chemotherapy-related complications allowed to perform chemotherapy without delay and dose reduction, and decrease the incidence of gastrointestinal toxicity in the form of emetic syndrome by 30.0%, early hepatotoxicity — by 8.2% and early cardiovascular toxicity — by 25.1%, as a result has been improved outcomes and quality of life of patients.
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