Experience of the National Cancer Institute performing nerve-sparing radical hysterectomy in patients with invasive cervical cancer

Dermenzhy T.

Summary. The abstract is devoted to the improvement of treatment effectiveness and quality of life of the patients with infiltrative cervical cancer by improving radical hysterectomy (RHE) via using nerve-sparing method. The dissertation is based on analysis of retrospective data on 120 patients with infiltrative cervical cancer cured during the last 14 years by combined method in accordance with the standards of Ministry of Health of Ukraine, and prospective data on clinical observation and treatment results of 90 patients with infiltrative cervical cancer treated in the Department of Oncogynecology of National Cancer Institute in 2012–2020 by nerve-sparing radical hysterectomy (NSRE; the main group, n = 45), and RHE III, (the control group, n = 45). It has been shown that 5-year survival index in the group with nerve-sparing RHE was 81.0±10.6% vs 73.7±16.2% in the group with RHE III. The conduction of NSRE in the patients with infiltrative cervical cancer has allowed to decrease significantly the rate of complications of genitourinary system which usually develop after convenient RHE III: difficulty with urinary bladder emptying in RHE III group was significantly increased compared with NSRE group 3.93±0.06 and 1.09±0.04 (р <0.05); dyspareunia — 4.69±0.07 and 2.87±0.07 (р <0,05) respectively. After conduction of NSRE there were observed no changes in the degree of bladder wall compliance and its volume, the changes of detrusor pressure were not registered that allowed to provide an adequate urination and continence, and did not worsen the quality of life of the patients. The indexes of role-physical functioning and mental health evidenced that just in 3 and 6 months after surgical treatment the patients with NSRE recovered more often that the patients after RHE III. The data mentioned above evidence on high effectiveness of nerve-sparing technologies for treatment of patients with cervical cancer and their positive influence on the quality of life.

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