Influence of neoadjuvant targeted therapy on quality of life in patients with localized renal cell carcinoma
Summary. Objective. To determine the impact of neoadjuvant targeted therapy (ТТ) on quality of life in patients with localized renal cell carcinoma (RCC). Маterials and methods. 75 patients with localized RCC, who underwent 2 cycles of neoadjuvant TT in the period from 2017 to 2019, determining the quality of life using the Short Form (SF)-36 questionnaire before and during the TT. Results. A statistically significant decrease in the majority components of quality of life was identified: PF (Physical Functioning), RP (Role — Physical), GH (General Health), VT (Vitality), SF (Social Functioning); and RE (Role — Emotional) (p<0.05), resulting from the impact of adverce events of TT on the physical and psychological state, which led to the restriction of patients’ social activity. TT was not accompanied by a decrease in median BP (Bodily pain) (p=0.51) and MH (Mental Health) (p=0.6). Conclusion. Neoadjuvant TT of localized RCC leads to a statistically significant decrease in the majority components of physical and mental health (SF-36) (p<0.05), which is associated with the adverse events of TT, except for the intensity of pain (p=0.51) and depressive disorders (p=0.6) due to the lack of progression and the prospect of nephron sparing surgery.
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