Effect of the neoadjuvant chemotherapy on surgical treatment muscle-invasive bladder cancer.

Stakhovsky О., Vitruk Iu., Voylenko O., Vucalovych P.S.

Summary. The aim of the work was to study the influence of neoadjuvant chemotherapy of the tumor process and surgical treatment of muscle-invasive bladder cancer. Prospectively evaluated the effectiveness of neoadjuvant chemotherapy and quality of life in 41 patients with muscle-invasive bladder cancer. Complete response of tumors diagnosed in 4 (9.8%), partial response — in 24 (58.5%), stable disease — in 11 (26.8%) and progressive disease — in 2 (4.9%) patients. In 4 (9.8%) cases the control cystoscopy with transurethral biopsy of the bladder wall, in 6 (14.6%) — open, in 18 (43.9%) — transurethral resection bladder wall of the tumor and 11 (26.8%) —a radical cystectomy was done. In 2 (4,9%) patient with absolute contraindications to cystectomy, performed palliative transurethral resection  of the bladder wall of the tumor. The neoadjuvant chemotherapy reliably cause regression of muscle-invasive bladder cancer in 68.3%, reducing the depth of invasion in 26.8% cases, that allows you to perform organ-sparing surgery and thus increases your overall 2-year survival rate to 85,4% and improves quality of life by 25%.
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