Multifocal growth of non-small cell lung cancer as evidence of a single source of development
Bolhova L.S., Med V.V., Borysyuk B.O.
Summary. Non-small cell lung cancer (NSCLC) is the most deadly malignant disease in the world, which encourages researchers to study in-depth the problems of its development to improve the effectiveness of treatment. The aim is to determine the growth characteristics of NSCLC based on clinical, macroscopic and histological studies of surgical material. Material and methods. The clinical, macroscopic features of the surgical material and the histological structure of 30 patients (15 — glandular and 15 — squamous cell type of lung cancer (LC)) who were examined and treated at the Nonprofit Organization National Cancer Institute were studied. Monoclonal antibodies were used to determine the proliferative activity of cells. Results. It was found that both histological types of LC grow in the form of multiple nodes (40–53%), often do not have clear peripheral contours in the lung parenchyma and are characterized by a prevalence of growth of 67%.In the preparations of all 30 patients, areas of bronchioloalveolar LC and tumor growth from the basement membrane of the alveolus to its center were detected. Conclusions. We have established a multinodular widespread growth of NSCLC and its development from stem cells from the basement membrane of the alveoli to their center, which we have described for the first time in the literature, and explains the possibility of multicentric, asymptomatic onset of growth in one or more lobes of the lung. The results of the study justify the need to seek improvements in morphological diagnostics and modern adequate therapy.
Leave a comment