Role of genetic polymorphism of glutathione-S-transferase in the prediction of chemotherapy complications

Sivak L.A., Lyalkin S., Khranovskaya N.M., Filonenko Е., Aleksyk O.M., Gubаrеvа А.А., Svеrgun N.N., Mаydаnеvich N., Klimаnоv М.Yu., Askоlskiy А.В.

Summary. Most patients with malignant breast tumors require chemotherapy. Often, complications that developed as a result of chemotherapy, significantly impair the efficacy of treatment and reduce patients quality of life. Study of the gene polymorphism of glutathione-s-transferases in patients receiving chemotherapy is a promising molecular genetic diagnostic criterion for identifying the risk of complications, individual risk assessment and implementation of preventive measures to reduce the toxicity of chemotherapy.
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