Neoadjuvant polychemotherapy within combined treatment gastric cancer patients: rationale use and evaluation of effectiveness

Kolesnik E.A., Lukashenko A., Burlaka A.A., Rozumiy D.A., Grabovoy A.N., Chalileev O.O. , Razumeiko I.

Summary. In the article the analysis of efficiency of using of neoadjuvant chemotherapy mode in the combined treatment of a gastric cancer patients was done. Results of own investigations of neoadjuvant chemotherapy (PELF) followed by further operative treatment are shown. Correlations between expression levels of molecular marker VEGFR-1 and gastric cancer tumour cells sensitivity to chemotherapy were found. The data of foreign authors and own investigations about prospects of using of biological markers for the purpose of studying of gastric cancer cells sensitivity to chemotherapy were summarized. Performed analysis is an evidence of urgency and practical importance of the modern molecular technologies application for the purpose of stomach cancer patients treatment algorithms improvement.
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