Drugs used as radiosensitizers: clinical and pharmaceutical aspects and prospects (literature review)
Andrushchenko I.V., Afanasieva I.O.
Summary. Malignant neoplasms are one of the most acute problems in modern medicine, claiming millions of lives worldwide annually. According to the World Health Organization (WHO), one in five people on the planet dies from cancer. In Ukraine, this figure exceeds 60,000 annually. Among the comprehensive approaches to combating cancer, radiation therapy holds a important place as a necessary method for over half of oncology patients. Tumor hypoxia is an obstacle to the effectiveness of radiation therapy. Radiosensitizers help overcome this and achieve the desired result by increasing the sensitivity of hypoxic tumors to ionizing radiation. The article summarizes information about radiosensitizers: their action models, pharmacokinetic characteristics, and the challenges and prospects for their improvement and application.
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