Bronchioloalveolar lung cancer in each non-small cell type
Bolgova L.S., Med V.V., Borysyuk B.O.
Summary. Lung cancer (LC) is the most common cancer in the world. The high morbidity and mortality from this disease requires comprehensive research. LC is diagnosed in the late stages, which raises the question of determining the causes of the current situation. One of the primary tasks is to determine the histogenesis of LC, which determines the issues of radiological and morphological diagnostics, and therefore the effectiveness of treatment. Aim — to identify areas of bronchioloalveolar lung cancer (BALC) in the structure of non-small cell type to clarify the onset of development. Material and methods of the study. Serial sections of surgical material from 30 patients with non-small cell. We used the hematoxylin and eosin, Howell, Black staining method and performed immunohistochemical studies with DAKO monoclonals — Ki-67 and proliferating cell nuclear antigen (PCNA). Results of the study. A special detailed study of serial sections of preparations from 30 patients with non-small cell LC allowed us to identify areas of BALC in all histological preparations and confirm the beginning of its growth from the basal cells of the alveoli by morphological and immunohistochemical indicators. Conclusions. Histological studies of serial sections of surgical material from patients with non-small cell LC allowed us to identify areas of typical BALC structure in all preparations with the determination of the beginning of growth from the basement membrane of the lung to its center, which is confirmed by a number of morphological and immunohistochemical indicators and is an evidentiary justification of the histogenesis of LC from stem cells.
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