Functional status of the thyroid gland as a factor modifying the level of PD-L1 expression by tumor cells and immunocompetent T cells of the paratumoral microenvironment
Kolomiiets А.А.1,2, Lyalkin S.A.1
- 1Nonprofit Organization National Cancer Institute, Kyiv, Ukraine
- 2P.L. Shupyk National University of Healthcare of Ukraine, Kyiv, Ukraine
Summary. The article outlines potential mechanisms of the influence of the functional status of the thyroid gland on the level of programmed cell death receptor ligand-1 (PD-L1) expression by tumor cells and immunocompetent T-cells of the paratumoral microenvironment. Factors influencing PD-L1 expression within the framework of Tumor Proportion Score (TPS) and Combined Positive Score (CPS) for different types of tumors by primary localization of the process, respectively, are considered separately. Also, a theoretical justification of the influence of the degree of tumor differentiation according to the Nottingham classification in the context of the influence of the functional status of the thyroid gland on TPS and CPS is provided. The objective. To investigate the potential of the functional status of the thyroid gland as a factor in modifying the level of PD-L1 expression by tumor cells and immunocompetent T cells of the paratumoral microenvironment. Results. The potential of the functional status of the thyroid gland as a factor in modifying the level of PD-L1 expression by tumor cells and immunocompetent T cells of the paratumoral microenvironment was investigated. Conclusions. The state of hypo-, hyper- or euthyroidism may affect PD-L1 expression not only at the stage of biopsy material collection for immunohistochemical examination, but also at other stages of the therapeutic and diagnostic process. The effectiveness of immunotherapeutic treatment with immune checkpoint inhibitors may differ in patients with different functional status of the thyroid gland and its changes in dynamics, as well as in patients with primary tumors with different degrees of differentiation according to the Nottingham classification, which requires further research at the intersection of oncology, endocrinology, pathomorphology and immunology.
Leave a comment