Number Т. 10, № 1-2 (37-38) 2020

Immunomonitoring of children with prognostic unfavourable soft tissue sarcomas during complex treatment

Shumilina К.S., Grinevich Yu.A. , Kukushkina S.М., Lоn A.D., Fil’chakov F.V., Shida E.V.

Summary. The condition of immune system at 42 children with prognostic unfavourable soft tissue sarcomas during complex treatment is investigated: 32 patients with for the first time established diagnosis and 10 — finished treatment and taking place in a condition of remission. At surveyed children disorders both in cellular and in humoral component of immune system are observed. That is shown by reduction of quantity of CD3 +-, CD20 +-, CD4 +-, CD8 +-lymphocytes, decrease of total lymphocytes in peripheral blood, and also dysimmunoglobulinemia. Carrying out of intensive polychemotherapy aggravates disorders in immune system of these children which are not restored in 1–2 years after the ending of treatment. Children who are taking place in a condition of remission, have less deep disorders of a cellular link of immune system directly after the ending of treatment; later 12 months all parameters are restored up to a level at practically healthy children. The revealed disorders in immune system of children prove necessity immunorehabilitation which can increase efficiency of their treatment with prolongation of recurrence-free period and increase in survival rate.
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